Beyond Atopy

A Review of Psychosocial Risk Factors for Pediatric Atopy

Pediatric atopy is increasing in prevalence and creates a significant financial and quality of life burden for children and families (e.g., frequent clinic visits, academic, and social challenges). Thus, it is important to understand modifiable risk factors related to disease onset or exacerbation in young children. The existing research base suggests that while a genetic link has been identifi...

Lichen simplex chronicus, neurotic excoriation and nodular prurigo and their correlation with atopy: A case-control study

Background: Lichen simplex chronicus (LSC), nodular prurigo (NP), and neurotic excoriation (NE) are considered as psychogenic pruritus disorders. Atopic dermatitis (AD) is also classified by some as a psychocutaneous disorder to point out the influence of psychologic factors in its recurrence, persistence and precipitation. AD and psychogenic pruritus share many common features including ...

Utility of the Atopy Patch Test in the Diagnosis of Allergic Rhinitis

Introduction: The diagnostic work-up of allergic rhinitis (AR) is first and foremost based on the combination of clinical history data and results of skin prick tests (SPT). Other tests, including specific IgE measurement, nasal challenge, and, as a third option, component resolved diagnosis or basophil activation test, may be useful when the diagnosis is difficult because of polysensitization ...

Mimicking microbial 'education' of the immune system: a strategy to revert the epidemic trend of atopy and allergic asthma?

Deficient microbial stimulation of the immune system, caused by hygiene, may underly the atopy and allergic asthma epidemic we are currently experiencing. Consistent with this 'hygiene hypothesis', research on immunotherapy of allergic diseases also centres on bacteria-derived molecules (eg DNA immunostimulatory sequences) as adjuvants for allergen-specific type 1 immune responses. If we unders...

Evidence for linkage between asthma/atopy in childhood and chromosome 5q31-q33 in a Japanese population.

Susceptibility to the development of asthma and other atopic diseases is known to be associated with genetic components, and several candidate genes have been reported to be linked to atopy in Caucasian populations. We conducted a study of linkage between asthma and markers on chromosomes 5q31-q33 and 11q13 in 68 Japanese families (306 members) by affected sib-pair analysis. Families for the li...

Specific IgE Assay for Respiratory Allergens in Patients with Atopy in Ahvaz, Iran